Developing Magnetic Resonance Imaging Biomarkers of Neuroinflammation, Cognitive Impairment, and Survival Outcomes for Radiotherapy-Induced Brain Injury in a Preclinical Mouse Model
Here, we identified 3 types of translational MRI biomarkers of RIBI that could enable the noninvasive longitudinal evaluation of potential RIBI prophylactic and therapeutic agents. These translational MRI biomarkers could also play a pivotal role in the management of RIBI in brain tumor survivors.
Authors
- Ethel J. Ngen
- Adnan Bibic (ORCID: https://orcid.org/0000-0001-8044-2906)
- Chantelle E. Terrillion (ORCID: https://orcid.org/0009-0005-9266-8845)
- Xiaochun Yang (ORCID: https://orcid.org/0000-0002-0057-0922)
- Speaker Soyoung Lee
- Esteban Velarde
- Maya Teitz
- Kristen Lecksell
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Anna Needs Neuroblastoma Answers (US)
Publication Details
- Journal
- Investigative Radiology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1097/rli.0000000000001173
- Citations
- 2
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.68