Ruthenium(<scp>ii</scp>)-catalyzed synthesis of poly-substituted furans <i>via</i> intermolecular oxidative annulation of 3-(phenylethynyl) oxazolidin-2-ones
This study presents a new method for the synthesis of poly-substituted furans by an oxidative annulation reaction of ynamides in the presence of Ru(II) as a catalyst, copper(II) triflate Cu(OTf)<sub>2</sub> as an oxidant, and cesium carbonate (Cs<sub>2</sub>CO<sub>3</sub>) as a base. The reaction shows broad substrate scope and compatibility with readily available starting materials, with yields ranging from good to excellent.
Authors
- Tadigoppula Narender (ORCID: https://orcid.org/0000-0002-2290-2764)
- Mohit Chourasiya
- Ruchir Kant
- Vikrant Nawal Vikram
Institutions
- Central Drug Research Institute (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d4ob02098g
- Primary Topic
- Catalytic Alkyne Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00