Correlation between Systemic Inflammation and Morphological Changes of Retinal Neurovascular Unit in Patients with Early Signs of Diabetic Retinopathy: An OCT and OCT-Angiography Study
Systemic inflammation biomarkers including NLR, MLR, and SII are significantly associated with not only retinal microvascular alterations but also retinal neuronal changes, providing evidence that systemic inflammation may play a crucial role on the early morphological changes of RNVU and early DR pathogenesis. SII is independently associated with VD, which supports SII may serve as a potential biomarker for monitoring early microvascular changes of DR.
Authors
- Hanli Guo
- Qiong Li (ORCID: https://orcid.org/0000-0001-9044-0074)
- Wenjie Wu (ORCID: https://orcid.org/0000-0001-7019-7935)
- Ningyi Jin (ORCID: https://orcid.org/0000-0001-7823-0576)
- Yue Huang (ORCID: https://orcid.org/0000-0003-4598-3146)
- Yulong Huang (ORCID: https://orcid.org/0000-0002-6188-5178)
- Hong Ma (ORCID: https://orcid.org/0000-0002-4729-8794)
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Ophthalmic Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1159/000545097
- Citations
- 1
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 1.36
Funders
- Natural Science Foundation of Fujian Province