Perceptual Visual Acuity Declines With Age in a Rat Model of Retinitis Pigmentosa While Light Perception is Maintained
Our findings suggest that form vision is primarily affected by the progression of RP, whereas non-form vision is potentially robust to retinal degeneration. This maintenance of light perception is likely due to the preserved function of intrinsically photosensitive retinal ganglion cells. These results provide useful and fundamental knowledge for evaluating the protective or restorative effects of experimental treatments for RP.
Authors
- Shogo Soma (ORCID: https://orcid.org/0000-0002-7381-9477)
- Akihiro Kimura (ORCID: https://orcid.org/0000-0001-5614-8547)
- Satoshi Shimegi (ORCID: https://orcid.org/0000-0002-5635-6669)
- Naofumi Suematsu (ORCID: https://orcid.org/0000-0002-5431-1723)
- Akinori Sato (ORCID: https://orcid.org/0000-0001-9011-1756)
Institutions
- University of Pittsburgh (US)
- Kyoto Prefectural University of Medicine (JP)
- Osaka Health Science University (JP)
- Nagoya University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1167/iovs.66.3.31
- Citations
- 1
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81