Associations of metabolic status with all-cause mortality among individuals with osteoarthritis: A prospective cohort study
OA is the leading joint disease worldwide, carrying a heavy health burden. Our newly established definition, evaluating metabolic health through waist-to-hip ratio, BMI, blood pressure, glucose, lipids, and C-reactive protein, identified 36.0 % OA patients in UK Biobank and 39.1 % OA patients in NHANES as having poor metabolic status, which is applicable in clinical and research settings. This study also showed that poor metabolic status, as classified by these criteria, is significantly correlated with an elevated risk of all-cause mortality in OA patients. It further highlights the importance of maintaining a holistic approach to care for OA patients, emphasizing the need to address both joint and metabolic health.
Authors
- Muhui Zeng (ORCID: https://orcid.org/0000-0002-4347-3495)
- Changhai Ding (ORCID: https://orcid.org/0000-0002-9479-730X)
- Xiaofeng Fang (ORCID: https://orcid.org/0000-0003-1003-5146)
- Zhaohua Zhu (ORCID: https://orcid.org/0000-0003-3913-2564)
- David John Hunter (ORCID: https://orcid.org/0000-0003-3197-752X)
- Zhong Alan Li (ORCID: https://orcid.org/0000-0002-6009-629X)
- Haowei Chen (ORCID: https://orcid.org/0000-0003-1466-5348)
- Xiaoshuai Wang (ORCID: https://orcid.org/0000-0002-3895-1384)
- Tianxiang Fan (ORCID: https://orcid.org/0000-0003-3781-924X)
- Hao Yang (ORCID: https://orcid.org/0009-0008-8919-5938)
Institutions
- The University of Sydney (AU)
- University of Tasmania (AU)
- Hong Kong Polytechnic University (HK)
- Chinese University of Hong Kong (HK)
- Royal North Shore Hospital (AU)
- General Hospital of Guangzhou Military Command (CN)
- Guangzhou First People's Hospital (CN)
- Zhujiang Hospital (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
- Southern Medical University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Orthopaedic Translation
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.jot.2025.02.004
- Citations
- 5
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- National Natural Science Foundation of China
- Guangzhou Science and Technology Program key projects