The Prevalence of the Thrombotic SNPs rs6025, rs1799963, rs2066865, rs2289252 and rs8176719 in Patients with Venous Thromboembolism in the Czech Population

IntroductionStudy aimed to determine the occurrence of 5 thrombosis-related single-nucleotide polymorphisms (SNPs) in patients with venous thromboembolism (VTE) (n = 2630) and a control group (n = 2637) in the Czech population.MethodsThe following gene SNPs were detected in both groups: <i>F5</i> Leiden (rs6025), <i>F2</i> (rs1799963), <i>FGG</i>, fibrinogen gamma' (rs2066865), <i>F11</i> (rs2289252) and <i>ABO</i> (rs8176719). Statistical analysis was performed using SAS statistical software with population genetics tools.ResultsHeterozygotes for <i>F5</i> Leiden were associated with a 5.58-fold and homozygotes <i>F5</i> Leiden with a 33.46-fold increased risk of VTE. At SNP rs1799963 (<i>F2</i>, prothrombin), only heterozygotes had a significant 3.9-fold increased risk of VTE. The findings at SNP rs2066865 (fibrinogen gamma', <i>FGG</i>) showed a 1.37-fold increased risk of VTE for <i>FGG</i> heterozygotes and a 1.77-fold increased risk of VTE for <i>FGG</i> homozygotes. There is also a significant 1.42-fold increase risk of VTE in the heterozygotes and a 1.80-fold increase risk of VTE in the homozygotes of the SNP rs 2289252 (<i>F11</i>). Further higher increases in the risk of VTE in both variants were found in patients with VTE at rs8176719 (<i>ABO</i>, non-O). It corresponds to a 2.2-fold increase in the risk of VTE in heterozygotes and a 3.5-fold increase in the risk of VTE in homozygotes.ConclusionBesides <i>F5</i> Leiden and prothrombin mutation, the study suggests that the gene polymorphisms of <i>FGG</i> (rs2066865), <i>F11</i> (rs2289252) and <i>ABO</i> (rs8176719) play a role as an independent heritable risk factor for VTE in the Czech population.