Co-delivery of circCDR1 and temozolomide with hyaluronic acid-chitosan nanoparticles inhibits glioma progression

Chemotherapeutic drug/gene nanoparticles (NPs) co-delivery system has great potential in tumor therapy. However, the role of circular RNA (circRNA) cerebellar degeneration-related 1 (CDR1) (circCDR1) and temozolomide (TMZ) NPs in the treatment of glioma remains unclear. circCDR1 was significantly low expressed in glioma tissues and cells. In the term of mechanism, circCDR1 could sponge miR-890 to regulate GJB6. The inhibition of circCDR1 on glioma progression could be reversed by miR-890, and the suppressive effect of miR-890 inhibitor on glioma progression also could be overturned by GJB6 silencing. CNPs could introduce TMZ and circCDR1 into glioma cells. The inhibitory effects of CNPs on glioma cell progression and tumor growth were much better than TMZ, TNPs and CNPs. Our study showed that circCDR1 could regulate the miR-890/GJB6 axis to inhibit glioma progression, and the constructed CNPs had a good inhibitory effect on glioma progression.