Dysregulation of Retinal Melatonin Biosynthetic Pathway and Differential Expression of Retina-Specific Genes Following Blast-Induced Ocular Injury in Ferrets
These findings highlight the complex regulatory mechanisms underlying retinal responses to bTOI, involving neuroinflammation, oxidative stress, and disruptions in melatonin synthesis and photoreceptor cell functions. The results emphasize the therapeutic potential of melatonin in mitigating retinal damage and preserving visual function.
Authors
- Peethambaran Arun (ORCID: https://orcid.org/0000-0002-0975-412X)
- Manoj Govindarajulu (ORCID: https://orcid.org/0000-0003-4739-648X)
- Chetan Pundkar (ORCID: https://orcid.org/0000-0001-8864-8546)
- Rex Jeya Rajkumar Samdavid Thanapaul (ORCID: https://orcid.org/0000-0002-5760-9437)
- Joseph B. Long
- Gaurav Phuyal
Institutions
- National Academies of Sciences, Engineering, and Medicine (US)
- Walter Reed Army Institute of Research (US)
Publication Details
- Journal
- Neurology International
- Published
- 2025-03-17
- DOI
- https://doi.org/10.3390/neurolint17030042
- Citations
- 4
- Primary Topic
- Photoreceptor and optogenetics research
- Type
- article
- Field-Weighted Citation Impact
- 3.64