Synergistic Neuroprotective and Immunomodulatory Effects of Cocoa Seed Husk and Guarana Extract: A Nutraceutical Approach for Parkinson’s Disease Management
GuaCa shows promise as a nutraceutical for managing neuroinflammation and mitochondrial dysfunction in PD. Further clinical studies are needed to confirm GuaCa extract efficacy and potential for neuroprotective dietary strategies.
Authors
- Erickson Oliveira dos Santos (ORCID: https://orcid.org/0000-0002-4569-905X)
- Vanusa do Nascimento (ORCID: https://orcid.org/0000-0003-4141-2784)
- Maria Fernanda Mânica-Cattani (ORCID: https://orcid.org/0000-0002-1722-6933)
- Fernanda Barbisan (ORCID: https://orcid.org/0000-0002-2960-7047)
- Ivana Beatrice Mânica da Cruz (ORCID: https://orcid.org/0000-0003-3008-6899)
- Ednéa Aguiar Maia Ribeiro
- Raquel de Souza Praia
- Railla da Silva Maia
- Cleideane Cunha Costa (ORCID: https://orcid.org/0000-0001-6782-3595)
- Verônica Farina Azzolin (ORCID: https://orcid.org/0000-0002-8191-5450)
- Vitória Farina Azzolin
- Bárbara Osmarin Turra (ORCID: https://orcid.org/0000-0003-4175-9534)
- Nathália Cardoso de Afonso Bonotto (ORCID: https://orcid.org/0000-0003-3733-3549)
- Marco Aurélio Echart Montano (ORCID: https://orcid.org/0000-0003-2014-1719)
- Juliane Santiago Sasso
- P. González (ORCID: https://orcid.org/0000-0002-1120-4047)
- Euler Esteves Ribeiro (ORCID: https://orcid.org/0000-0003-3878-1933)
- Douglas Reis Siqueira
- Cristina Maranghello
Institutions
- Universidade Federal de Santa Maria (BR)
- Faculdade da Serra Gaúcha (BR)
- Samsung (Brazil) (BR)
- Universidade São Judas Tadeu (BR)
- Universidade Federal do Amazonas (BR)
Publication Details
- Journal
- Antioxidants
- Published
- 2025-03-15
- DOI
- https://doi.org/10.3390/antiox14030348
- Citations
- 1
- Primary Topic
- Phytochemicals and Antioxidant Activities
- Type
- article
- Field-Weighted Citation Impact
- 0.77