Efficacy and safety of andexanet alfa for factor Xa inhibitor-associated intracranial haemorrhage
The present meta-analysis suggests AA is associated with improved haemostatic efficacy compared with usual care, with no significant differences observed in functional and safety outcomes. These findings indicate that AA may have a role in the management of factor Xa inhibitor-associated ICH, although further high-quality studies are needed to better define its net clinical benefit.
Authors
- Maria‐Ioanna Stefanou (ORCID: https://orcid.org/0000-0002-2305-6627)
- Georgios K. Tsivgoulis (ORCID: https://orcid.org/0000-0002-0640-3797)
- Aikaterini Theodorou (ORCID: https://orcid.org/0000-0001-7229-2610)
- Michele Romoli (ORCID: https://orcid.org/0000-0001-8009-8543)
- Lina Palaiodimou (ORCID: https://orcid.org/0000-0001-7757-609X)
- Christos Krogias (ORCID: https://orcid.org/0000-0003-2965-4051)
- Ashkan Shoamanesh (ORCID: https://orcid.org/0000-0002-2802-1626)
- Theodoros Karapanayiotides (ORCID: https://orcid.org/0000-0002-2357-7967)
- Thorsten Steiner (ORCID: https://orcid.org/0000-0002-5080-8222)
- Aristeidis H. Katsanos (ORCID: https://orcid.org/0000-0002-6359-0023)
- Amrou Sarraj (ORCID: https://orcid.org/0000-0001-5726-4478)
- Marios Themistocleous (ORCID: https://orcid.org/0000-0003-3810-8001)
- Carlos A. Molina (ORCID: https://orcid.org/0000-0001-6058-6259)
Institutions
- Hebron University (PS)
- National and Kapodistrian University of Athens (GR)
- Heidelberg University (DE)
- University Hospitals of Cleveland (US)
- AHEPA University Hospital (GR)
- University Hospital Heidelberg (DE)
- Population Health Research Institute (CA)
- Ospedale “M. Bufalini” di Cesena (IT)
- Klinikum Frankfurt Höchst (DE)
- Vall d'Hebron Hospital Universitari (ES)
- University General Hospital Attikon (GR)
- Ruhr University Bochum (DE)
- McMaster University (CA)
Publication Details
- Journal
- Journal of Neurology Neurosurgery & Psychiatry
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1136/jnnp-2024-335558
- Citations
- 2
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.78