Causal Relationships Between Inflammatory Cytokines and Sepsis: A Mendelian Randomization Study.
This study reveals novel causal relationships between specific inflammatory cytokines and sepsis, suggesting that CTACK, MIF, and TRAIL are risk factors, while MIP1-β and TGF-<i>α</i> are protective. Additionally, sepsis influences various cytokines, indicating complex bi-directional interactions. These findings provide valuable insights for developing targeted therapeutic strategies to manage sepsis and inflammatory responses.
Authors
- Donglai Feng (ORCID: https://orcid.org/0000-0001-9370-5357)
- Tingqiu Wei
- Qin Jiang (ORCID: https://orcid.org/0000-0002-0689-8304)
- Feng Lu (ORCID: https://orcid.org/0000-0003-4868-7908)
- Yizhen Yan (ORCID: https://orcid.org/0000-0001-7508-9861)
- Zheyi Zhou (ORCID: https://orcid.org/0009-0000-2540-4595)
- Cuilan Chen
- Ying Zhong (ORCID: https://orcid.org/0000-0002-8498-1373)
- Jing Qin (ORCID: https://orcid.org/0000-0002-8327-8846)
- Xuan Tang (ORCID: https://orcid.org/0000-0001-9557-2068)
Institutions
- Liuzhou Maternal and Child Health Hospital (CN)
- Liuzhou General Hospital (CN)
Publication Details
- Journal
- PubMed
- Published
- 2025-01-01
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00