P107: Co-existing t(9;14)(q33;q32)/IGH rearrangement is a risk factor for lymphoid blast phase transformation of chronic myeloid leukemia
Secondary genetic abnormalities in addition to increased BCR::ABL1 transcript levels are risk factors for chronic myeloid leukemia (CML) transformation from chronic phase (CP) to blast phase (BP), especially myeloid BP. Risk factors for lymphoid BP are poorly characterized, but some studies have implicated oligoclonal recombination of immunoglobulin genes (IGH, IGK, and IGL). We sought to determine the incidence of IGH rearrangement in CML lymphoid BP cases.
Authors
- Jesse L. Cox (ORCID: https://orcid.org/0000-0002-4590-7381)
- Allison M. Cushman‐Vokoun (ORCID: https://orcid.org/0009-0005-0028-9371)
- Guilin Tang (ORCID: https://orcid.org/0000-0002-9482-4806)
- Ketav Desai
- Shanxiang Zhang (ORCID: https://orcid.org/0000-0001-8525-7021)
- Chang‐Qing Xia (ORCID: https://orcid.org/0000-0002-3832-1091)
- Arash Ronaghy (ORCID: https://orcid.org/0000-0001-8870-7139)
- Zhenya Tang (ORCID: https://orcid.org/0000-0002-8079-9945)
- Saber Tadros (ORCID: https://orcid.org/0000-0002-2887-6122)
- Joseph David Khoury (ORCID: https://orcid.org/0000-0003-2621-3584)
- Hong Fang (ORCID: https://orcid.org/0000-0001-6214-2563)
- Wei J. Wang (ORCID: https://orcid.org/0000-0002-4848-7394)
- Allison Guild
- Weiwei Zhang (ORCID: https://orcid.org/0000-0003-3258-5528)
Institutions
- Scripps MD Anderson Cancer Center (US)
- University of Nebraska Medical Center (US)
Publication Details
- Journal
- Genetics in Medicine Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gimo.2025.102951
- Primary Topic
- Chronic Myeloid Leukemia Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00