P669: Empowering clinicians to resolve VUS: Presenting VUS clarification outcomes

Familial segregation studies provide essential, yet often underutilized, information for reclassifying Variants of Uncertain Significance (VUS). The VUS Clarification Service (VCS) program was designed to enhance the utility of familial segregation data. This unique approach offered a structured, three-tiered approach to assess potentially significant VUS and deliver customized guidance in clinical reports. In Tier 1, parental or offspring testing is performed to determine de novo status and phase without requiring a formal application or a formal application.