P822: Circulating cell-free DNA in the diagnosis of hydatidiform mole and digynic nonmolar triploidy

Hydatidiform mole (HM) and digynic nonmolar triploidy represent significant challenges in prenatal care, given their distinct chromosomal origins and the limitations of conventional diagnostic methods. Circulating cell-free DNA (cfDNA) has emerged as a promising non-invasive tool for the early detection of these gestational abnormalities, offering improved diagnostic accuracy, especially in cases where traditional imaging and histopathology may be inconclusive. This study investigates the potential of cfDNA analysis to distinguish between hydatidiform moles, characterized by an extra set of paternal chromosomes with abnormal trophoblastic proliferation, and digynic nonmolar triploidy, where an extra set of maternal chromosomes results in a nonviable fetus without molar characteristics.