Overexpression of Wild-Type TMEM43 Improves Cardiac Function in Arrhythmogenic Right Ventricular Cardiomyopathy Type 5
Overexpression of WT-TMEM43 improves the pathological phenotype in a mouse model of ARVC5. Adeno-associated virus-mediated delivery of WT-TMEM43 offers a promising and specific therapy for patients suffering from this highly lethal disease.
Authors
- R. J. Jiménez Riobóo (ORCID: https://orcid.org/0000-0002-9545-0172)
- Laura Lalaguna (ORCID: https://orcid.org/0000-0002-4737-358X)
- Pura Muñoz‐Cánoves (ORCID: https://orcid.org/0000-0002-7533-9047)
- Marina López‐Olañeta
- Joan Isern (ORCID: https://orcid.org/0000-0002-1401-9779)
- María Victoria Gómez‐Gaviro (ORCID: https://orcid.org/0000-0002-8683-5150)
- Pablo García‐Pavía (ORCID: https://orcid.org/0000-0002-5470-2257)
- María Villalba‐Orero (ORCID: https://orcid.org/0000-0002-7680-3980)
- Juan Pablo Ochoa
- Barry J. Byrne
- Enrique Lara‐Pezzi (ORCID: https://orcid.org/0000-0002-2743-1033)
- Miquel Arenas
Institutions
- Universidad Complutense de Madrid (ES)
- Universitat Pompeu Fabra (ES)
- Hospital General Universitario Gregorio Marañón (ES)
- University of Florida (US)
- Hospital Universitario Puerta de Hierro Majadahonda (ES)
- Centro de Investigación Biomédica en Red (ES)
- Instituto de Ciencia de Materiales de Madrid (ES)
- Light Prescriptions Innovators (Spain) (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Centro de Investigación Biomédica en Red de Cáncer (ES)
Publication Details
- Journal
- Circulation Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1161/circresaha.124.325848
- Citations
- 5
- Primary Topic
- Cardiovascular Effects of Exercise
- Type
- article
- Field-Weighted Citation Impact
- 6.94