Amyloid <scp>PET</scp> in Sporadic Early‐ Versus Late‐Onset Alzheimer's Disease: Comparison of the <scp>LEADS</scp> and <scp>ADNI</scp> Cohorts
Differences in the burden of amyloid pathology may contribute to differences in clinical and anatomic patterns in sporadic EOAD and LOAD, and have implications for optimizing therapeutic strategies in each group. ANN NEUROL 2025;98:236-248.
Authors
- Alexandra Touroutoglou (ORCID: https://orcid.org/0000-0001-9679-2433)
- Stephen Salloway (ORCID: https://orcid.org/0000-0002-2631-0942)
- Michael Brickhouse
- Lawrence S. Honig (ORCID: https://orcid.org/0000-0002-9703-2265)
- Alireza Atri (ORCID: https://orcid.org/0000-0003-4405-6973)
- Ranjani P. Shankar (ORCID: https://orcid.org/0009-0002-1726-9690)
- Piyush Maiti (ORCID: https://orcid.org/0009-0002-8006-1032)
- Renaud La Joie (ORCID: https://orcid.org/0000-0003-2581-8100)
- Daniel R. Schonhaut
- Julien Lagarde (ORCID: https://orcid.org/0000-0002-2018-261X)
- Alexander Taurone
- Ehud Zeltzer (ORCID: https://orcid.org/0000-0002-1146-0358)
- María C. Carrillo (ORCID: https://orcid.org/0000-0003-3057-2387)
- Joseph C. Masdeu (ORCID: https://orcid.org/0000-0001-9955-6954)
- Erik S. Musiek (ORCID: https://orcid.org/0000-0002-8873-0360)
- Ian Grant (ORCID: https://orcid.org/0000-0001-6960-6762)
- Liana G. Apostolova (ORCID: https://orcid.org/0000-0003-1823-2451)
- David A. Wolk (ORCID: https://orcid.org/0000-0002-3554-3481)
- Erik C. B. Johnson (ORCID: https://orcid.org/0000-0002-0604-2944)
- Jeffrey L. Dage (ORCID: https://orcid.org/0000-0002-2192-1699)
- Prashanthi Vemuri (ORCID: https://orcid.org/0000-0003-4286-0589)
- Chiadi U. Onyike (ORCID: https://orcid.org/0000-0003-2255-4437)
- Robert Koeppe
- Karen Smith
- Gil Dan Rabinovici (ORCID: https://orcid.org/0000-0002-3626-4265)
- Dustin B. Hammers (ORCID: https://orcid.org/0000-0002-1644-2618)
- Kyle Womack (ORCID: https://orcid.org/0000-0002-6060-9075)
- Sandra Rocha (ORCID: https://orcid.org/0000-0002-4530-3537)
- Laurel Beckett (ORCID: https://orcid.org/0000-0002-2418-9843)
- Sharon J. Sha (ORCID: https://orcid.org/0000-0002-3666-1463)
- Emily Rogalskı (ORCID: https://orcid.org/0000-0002-6472-1363)
- Isabel Elaine Allen (ORCID: https://orcid.org/0000-0001-9029-9744)
- David N. Soleimani‐Meigooni (ORCID: https://orcid.org/0000-0003-4197-3039)
- Gregory Scott Day (ORCID: https://orcid.org/0000-0001-5133-5538)
- Rema Raman (ORCID: https://orcid.org/0000-0002-4096-6390)
- Maison Abu Raya (ORCID: https://orcid.org/0000-0002-7272-2104)
- Kelly Nudelman (ORCID: https://orcid.org/0000-0003-4040-1717)
- Ganna Blazhenets (ORCID: https://orcid.org/0000-0003-2419-7373)
- Agathe Vrillon (ORCID: https://orcid.org/0000-0002-0761-7885)
- Charles Windon (ORCID: https://orcid.org/0000-0001-8719-1206)
- Mario F. Mendez (ORCID: https://orcid.org/0000-0001-6441-7989)
- Ani Eloyan (ORCID: https://orcid.org/0000-0002-8110-7680)
- Bradford Clark Dickerson (ORCID: https://orcid.org/0000-0002-5958-3445)
- Raymond Scott Turner (ORCID: https://orcid.org/0000-0001-7534-2935)
- Neill R. Graff‐Radford (ORCID: https://orcid.org/0000-0001-9847-9096)
- Alinda Amuiri
- Jinsong Zhang (ORCID: https://orcid.org/0000-0001-9366-9819)
- David Jones (ORCID: https://orcid.org/0000-0002-2036-5141)
- Thomas S. Wingo (ORCID: https://orcid.org/0000-0002-7679-6282)
- Paul Aisen
- Ranjan Duara
- Kala Kirby
- Maryanne Thangarajah
- Susan M. Landau
- Meghan Riddle
Institutions
- Northwestern University (US)
- University of Southern California (US)
- Alzheimer's Association (US)
- Autism Research Institute (US)
- Houston Methodist (US)
- Harvard University (US)
- Johns Hopkins University (US)
- Emory University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Georgetown University (US)
- Washington University in St. Louis (US)
- Cornell University (US)
- Brown University (US)
- University of Michigan (US)
- Columbia University Irving Medical Center (US)
- Johns Hopkins Medicine (US)
- Jacksonville College (US)
- WinnMed (US)
- University of California System (US)
- University of Chicago (US)
- Massachusetts General Hospital (US)
- Mount Sinai Medical Center (US)
- Methodist Hospital (US)
- Mayo Clinic in Arizona (US)
- Banner Sun Health Research Institute (US)
- Mayo Clinic in Florida (US)
- Global Brain Health Institute (US)
- Weill Cornell Medicine (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
- University of Pennsylvania (US)
- University of California, Davis (US)
- University of California, Berkeley (US)
- Stanford University (US)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1002/ana.27233
- Citations
- 7
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 10.30
Funders
- Alzheimer's Association
- National Institute on Aging