Effect of cystic fibrosis modulator therapies on serum levels of fat‐soluble vitamins
This is a prospective, multicenter study of a cohort of 224 cystic fibrosis (CF) patients treated with CF transmembrane conductance regulator (CFTR) modulators (CFTRm). Our aim was to prospectively analyze the effect of CFTRm treatment on fat-soluble vitamin serum levels. Demographic and clinical data were recorded, and fat-soluble vitamin levels were analyzed at baseline, and at 6 and 12 months after starting treatment. Two groups were analyzed separately: patients receiving dual therapy lumacaftor/ivacaftor or tezacaftor/ivacaftor (Lum/Tez+Iva), and those on triple therapy with elexacaftor/tezacaftor/ivacaftor (ETI). We found that treatment with ETI produced a significant increase in vitamin D and A levels within the first 6 months, which was maintained at 12 months. However, with dual therapy, we observed an increase only in vitamin A levels within the first 6 months, which was not maintained at 12 months. No differences were found in vitamin E serum levels between the groups.
Authors
- M. Garriga (ORCID: https://orcid.org/0000-0002-4683-2043)
- Sara María Fernández-González (ORCID: https://orcid.org/0000-0002-9255-5198)
- Carmen Martin‐Fernández (ORCID: https://orcid.org/0000-0003-0843-2580)
- David González Jiménez (ORCID: https://orcid.org/0000-0001-8696-9194)
- José Ramón Gutiérrez Martínez (ORCID: https://orcid.org/0000-0001-6724-6636)
- Ruth García‐Romero
- Saioa Vicente‐Santamaría (ORCID: https://orcid.org/0000-0003-2082-8983)
- Inés Loverdos (ORCID: https://orcid.org/0000-0002-5496-8717)
- Sara Sierra San Nicolás
- A De la Mano Hernández (ORCID: https://orcid.org/0000-0003-1790-1000)
- Pilar Ortiz Pérez (ORCID: https://orcid.org/0000-0002-6578-9503)
- Elena Crehuá‐Gaudiza (ORCID: https://orcid.org/0000-0001-7135-6539)
- Luis Peña Quintana (ORCID: https://orcid.org/0000-0001-6052-5894)
- R Castillo (ORCID: https://orcid.org/0000-0003-2536-9149)
- Enrique Salcedo Lobato
- Ana María Castro Millán
- Marina Álvarez Beltrán
- Camila García Volpe
- A. Carrillo Domínguez
- Cheryl Galindo (ORCID: https://orcid.org/0009-0002-7394-4355)
- Carlos Tutau Gómez
Institutions
- Universidad de Las Palmas de Gran Canaria (ES)
- Hospital Sant Joan de Déu Barcelona (ES)
- Universitat de València (ES)
- Hospital Universitario Insular de Gran Canaria (ES)
- Hospital Universitario de Canarias (ES)
- Hospital Clínico Universitario de Valencia (ES)
- Hospital Universitario 12 De Octubre (ES)
- Hospital Regional Universitario de Málaga (ES)
- Hospital Infantil Universitario Niño Jesús (ES)
- Hospital Universitario Miguel Servet (ES)
- Vall d'Hebron Hospital Universitari (ES)
- Hospital Universitario Central de Asturias (ES)
- Hospital de Cruces (ES)
- Complexo Hospitalario Universitario A Coruña (ES)
- Hospital Universitario Ramón y Cajal (ES)
Publication Details
- Journal
- JPGN Reports
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1002/jpr3.70007
- Citations
- 3
- Primary Topic
- Cystic Fibrosis Research Advances
- Type
- article
- Field-Weighted Citation Impact
- 4.56