Synthesis, Identification, and Antibacterial Effect Study of Some New Benzoxazepindions using Thiazolylimines

In this work, thiazolidinone scaffolds were condensed with different aromatic amines in 100% ethanol under reflux for six hours to create a novel series of Schiff base derivatives [A1–A8]. Benzoxazepine derivatives [A9–A16] were obtained by cyclizing these intermediates with phthalic anhydride in anhydrous benzene. FT-IR spectroscopy and physicochemical characterization were used to accomplish structural elucidation. Selected compounds were further validated by ¹H-NMR and ¹³C-NMR with DMSO-d6 as the solvent. Thin-layer chromatography was used to evaluate purity (TLC). Using Ciprofloxacin as a reference, the synthetic compounds' antibacterial effectiveness was evaluated against Gram-positive Staphylococcus aureus and Staphylococcus epidermidis, as well as Gram-negative Escherichia coli and Pseudomonas aeruginosa. Their potential as bioactive compounds was. highlighted by the results, which showed substantial inhibitory activity.