The novel house dust mite allergen Der p 39 exacerbates atopic dermatitis-like inflammation in mice by inducing skin barrier dysfunction
The HDM allergen Der p 39 enhances allergic inflammation and promotes MAPK pathway-mediated epidermal barrier dysfunction, suggesting that Der p 39 may possess pathogenic and clinically relevant immunomodulatory potential.
Authors
- Ze‐Lang Cai (ORCID: https://orcid.org/0000-0001-6394-1631)
- Liang Chen (ORCID: https://orcid.org/0000-0003-4274-8933)
- Wan-Zhen Hu
- Kunmei Ji (ORCID: https://orcid.org/0000-0002-5754-8697)
- Shan Liu (ORCID: https://orcid.org/0000-0003-2953-1801)
- Jiajie Chen (ORCID: https://orcid.org/0000-0002-1372-8450)
- Jingcheng Liu (ORCID: https://orcid.org/0000-0001-5883-3150)
- Shuping Que
Institutions
- Huaqiao University (CN)
- Shenzhen University (CN)
- Shenzhen University Health Science Center (CN)
- Xiamen Chang Gung Hospital (CN)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1016/j.waojou.2025.101036
- Citations
- 1
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Natural Science Foundation of Shenzhen City
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Fujian Provincial Department of Science and Technology
- Shenzhen Research Institute, City University of Hong Kong