Palladium-catalyzed cyclization reaction of 1,6-enynes and disilanes to synthesize silyl benzofurans

A protocol for the synthesis of silyl benzofuran <i>via</i> Pd-catalyzed tandem cyclization and silylation from easily accessible 1,6-enynes and disilanes has been established. This protocol features excellent functional group tolerance and mild reaction conditions, yielding benzofuran derivatives in moderate to good yields. This method realizes the construction of silyl benzofurans with disilanes as the silyl source.

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Publication Details

Journal
Chemical Communications
Published
2025-01-01
DOI
https://doi.org/10.1039/d5cc00332f
Primary Topic
Catalytic Cross-Coupling Reactions
Type
article
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article

Palladium-catalyzed cyclization reaction of 1,6-enynes and disilanes to synthesize silyl benzofurans

Guojun Yu, Tianqiang Wang, Rulong Yan, Gang Hu et al.
Chemical Communications
Catalytic Cross-Coupling Reactions
article

Palladium-catalyzed cyclization reaction of 1,6-enynes and disilanes to synthesize silyl benzofurans

Guojun Yu, Tianqiang Wang, Rulong Yan, Gang Hu, Chengcheng Zhang, Jieming Xie, Bo Zhao, Jiaze Qin
article en

Abstract

A protocol for the synthesis of silyl benzofuran <i>via</i> Pd-catalyzed tandem cyclization and silylation from easily accessible 1,6-enynes and disilanes has been established. This protocol features excellent functional group tolerance and mild reaction conditions, yielding benzofuran derivatives in moderate to good yields. This method realizes the construction of silyl benzofurans with disilanes as the silyl source.

Chemical CommunicationsVol. 61(31)
Jinchuan (China) (CN), Lanzhou University (CN)
Openalex Percentile: Top 96%
Catalytic Cross-Coupling Reactions
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