Suture‐Free Corneal Transplantation via Bioself‐Adhesive Lenticules Based on Macromolecular Electrostatic Entanglement

Abstract The corneal lenticules extracted from small incision lenticule extraction (SMILE) can be used as an optional corneal transplantation material. However, it cannot be used for deep anterior lamellar keratoplasty due to its thickness limitations. In this study, oxidized chondroitin sulfate (O─CS) containing ─SO 3 − groups can be twisted with generation 4.0 polyamidoamine dendrimers (G4 PAMAM) which contain −NH 2 + groups via electrostatic entanglement to form a cohesive corneal lenticule transplantation module, which is applicable in suture‐free transplantation of cornea, providing the possibility of repairing deep corneal defects. The intermolecular electrostatic entanglement enhanced the self‐adhesion of the corneal transplantation module (33.80 ± 2.12 kPa) with high light transmittance (more than 70%) and excellent biocompatibility, which benefits the stable adhesion in the long term. Additionally, G4 PAMAM can control long‐term puerarin drug release and then inhibit the postoperative inflammatory response. The bioself‐adhesion via the electrostatic entanglement between macromolecules can realize the suture‐free corneal transplantation between tissues, which provides a promising strategy for living tissue transplantation and wound repair.