Cuprate ion-pair catalyzed conjugate borylation of vinyl sulfones in a biphasic system
Herein we report the conjugate borylation of vinyl sulfones mediated by ion pairing, which enables the efficient synthesis of β-sulfonyl alcohols bearing diverse functionalities in 13-98% yields. Further mechanistic investigations suggest the formation of anionic boryl-copper intermediates that kinetically accelerate reactant transfer across phases and provide enhanced boryl nucleophilicity.
Authors
- Hong Qin (ORCID: https://orcid.org/0000-0003-0304-3762)
- Jinghua Tang (ORCID: https://orcid.org/0000-0003-3359-5891)
- Jin Tao (ORCID: https://orcid.org/0000-0002-8481-3732)
- Yicen Ge (ORCID: https://orcid.org/0000-0003-0653-8701)
- Ai Zhang (ORCID: https://orcid.org/0000-0002-8308-9973)
- Jinyu Liu (ORCID: https://orcid.org/0000-0002-3258-3242)
- Jianmin Chen (ORCID: https://orcid.org/0000-0001-5859-3070)
- Xiaoyan Ma (ORCID: https://orcid.org/0000-0002-4352-5427)
- Silong Hu
- Siyu Jiang
- Huangfeng Zhang
Institutions
- Chengdu University of Technology (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00242g
- Citations
- 3
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.81