Advances in Gene Therapy for Respiratory and Renal Diseases

Background: Respiratory and kidney diseases pose substantial challenges to global health, contributing significantly to morbidity and mortality worldwide.Current therapies for these diseases often focus on managing symptoms and decelerating disease progression, but they often fall short in addressing the genetic and molecular roots of these conditions.Gene therapy, which involves correcting or modifying genetic material to treat or prevent disease, has emerged as a promising approach for targeting both respiratory and kidney conditions.Methods: This review explores the recent advances in gene therapy that apply to respiratory and kidney disorders, with emphasis on innovative nanotechnology for gene delivery, emerging therapeutic targets, and the hurdles that must be overcome for clinical translation. Conclusion:The increasing number of efficient and safe gene therapy products highlights the significant therapeutic potential of this approach, offering durable and targeted solutions for treating respiratory and renal diseases.Ongoing advancements in delivery technologies and research efforts are crucial for overcoming current challenges and translating these therapies into widespread clinical applications.