Chikusetsusaponin IVa targeted YAP as an inhibitor to attenuate liver fibrosis and hepatic stellate cell activation
These findings demonstrated that the administration of CS-IVa effectively alleviated liver fibrosis by suppressing the YAP/TAZ pathways. In addition, CS-IVa could directly bind to YAP and act as a YAP inhibitor.
Authors
- Meina Zhao (ORCID: https://orcid.org/0009-0000-1645-6684)
- Xingru Tao
- Kai Gao (ORCID: https://orcid.org/0000-0002-0771-7755)
- Wei Zhang (ORCID: https://orcid.org/0009-0002-3507-4504)
- Jingwen Wang (ORCID: https://orcid.org/0000-0002-3450-9046)
- Dong Xu
- Yunyang Lu
Institutions
- Xijing Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s13020-025-01090-5
- Citations
- 2
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.64