Formulation and Evaluation of Solid Dispersion Tablets of Aceclofenac

Formulating the solid dispersion (SD) of the weakly water-soluble medication aceclofenac using various matrix types and creating tablets from the prepared SD of aceclofenac were the goals of this work. The solution approach was used to prepare the SD of aceclofenac utilizing a variety of matrices, including lactose, mannitol, and urea. The HPMC E15 LV polymer was used in the direct compression method to create the tablets. The granules were assessed by measuring their Carr's index, Hausner ratio, bulk density, tapped density, and angle of repose. The results are satisfactory. The tablets' hardness, friability, drug content, and in-vitro release were measured and examined. A pure drug's release study was carried out. It was evident from the results that pure aceclofenac dissolved relatively slow. The time at which aceclofenac dissolved was extremely quick when it was produced in SD form. Aceclofenac SD tablets were made, and a release analysis was conducted based on the different matrices employed in the process, such as urea, lactose, and mannitol. The SD of aceclofenac tablets with urea produces noticeably better results in the release studies compared to lactose and mannitol. Thus, long-term stability research is necessary for this formulation's future development. Keywords: Solid Dispersion, Aceclofenac, Lactose, Urea, Mannitol