Photocatalytic Three-Component Radical Sulfonarylation of Alkenes: Preparation of γ-Keto-Sulfone-Substituted Oxindoles
A photocatalytic radical sulfonarylation of <i>N</i>-arylacrylamides via a three-component cascade cyclopropyl alcohol ring opening/sulfur dioxide insertion/sulfonyl radical addition/cyclization sequence has been developed. This method employs cyclopropyl alcohols as the precursors of β-carbonyl alkyl radicals and Na<sub>2</sub>S<sub>2</sub>O<sub>5</sub> as a cheap source of sulfur dioxide. By using this cascade procedure, a wide variety of γ-keto-sulfone-substituted oxindoles were facilely synthesized.
Authors
- Yunhong Jia
- Yunhe Lv (ORCID: https://orcid.org/0000-0001-5804-7475)
- Zheng Yang (ORCID: https://orcid.org/0000-0002-3352-9440)
- Shu-Man Wang
- Yixin Zhu (ORCID: https://orcid.org/0000-0001-9841-3310)
- Fei Chen (ORCID: https://orcid.org/0000-0001-5145-6073)
- Yinan Zhang (ORCID: https://orcid.org/0000-0002-0362-1473)
- Yu-Xin Lai
- Shuliao Tian (ORCID: https://orcid.org/0009-0005-1968-0223)
- J. Li
- Jun-Ya Guo
Institutions
- Shanghai Normal University (CN)
- Institute of Molecular Functional Materials (CN)
- Anyang Normal University (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1021/acs.joc.4c03174
- Citations
- 6
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 5.62
Funders
- National Natural Science Foundation of China
- Foundation of Henan Educational Committee
- Natural Science Foundation of Henan Province
- Anyang Normal University