A comparative analysis of somatic mutational profiles according to HIV status among women with cervical intraepithelial neoplasia 3 (CIN3): a focus on hotspots in TP53, PIK3CA, PTEN, and EGFR
HIV-infection status and age appear to be risk factors for higher burden of pathogenic mutations in genes that predispose to cervical cancer. Mutation profiles in PIK3CA and TP53 genes could be biomarkers of cervical cancer progression but more studies are needed.
Authors
- Hue-Tsi Wu (ORCID: https://orcid.org/0000-0003-3353-8109)
- Collet Dandara (ORCID: https://orcid.org/0000-0002-5925-4895)
- Nyarai D. Soko (ORCID: https://orcid.org/0000-0003-1250-8293)
- Richard Naidoo (ORCID: https://orcid.org/0000-0003-0814-4829)
- Nosipho Mabizela
Institutions
- South African Medical Research Council (ZA)
- University of Cape Town (ZA)
- Harare Institute of Technology (ZW)
- Right to Care (ZA)
Publication Details
- Journal
- Infectious Agents and Cancer
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s13027-025-00647-1
- Citations
- 1
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 1.35