Metformin sensitizes triple-negative breast cancer to histone deacetylase inhibitors by targeting FGFR4
Metformin enhances the sensitivity of TNBC to HDAC inhibitors by blocking the FGFR4 pathway and interfering with metabolic reprogramming. When used in combination with SAHA, metformin exhibits synergistic antitumor effects. Our study provides a theoretical basis for the combined application of HDAC inhibitors and metformin, potentially offering a new strategy for the treatment of TNBC.
Authors
- Hong Luo (ORCID: https://orcid.org/0000-0001-8699-3856)
- Xiaoqing Jia (ORCID: https://orcid.org/0000-0002-4515-9678)
- Peizhen Wen
- Fugui Ye
- Yun Fu (ORCID: https://orcid.org/0000-0001-6574-7736)
- Zhangyuan Gu (ORCID: https://orcid.org/0000-0002-6498-5326)
- Jiejing Li (ORCID: https://orcid.org/0000-0001-9020-512X)
- Yue Gong (ORCID: https://orcid.org/0000-0002-6842-5318)
- Shiqi Mao (ORCID: https://orcid.org/0000-0001-8036-7336)
- Zhi‐Ming Shao (ORCID: https://orcid.org/0000-0001-8781-2455)
- Xiaoguang Li (ORCID: https://orcid.org/0000-0002-3345-1313)
- Xiangchen Han (ORCID: https://orcid.org/0000-0001-7894-7024)
- Bo-yue Han (ORCID: https://orcid.org/0000-0002-3064-0776)
- Xin Hu (ORCID: https://orcid.org/0000-0002-8915-3526)
- Xiaolin Cheng (ORCID: https://orcid.org/0000-0002-8420-1058)
- Zhigang Zhuang (ORCID: https://orcid.org/0000-0002-7827-4402)
Institutions
- Tongji University (CN)
- Shanghai Medical College of Fudan University (CN)
- Xiamen University (CN)
- Fudan University Shanghai Cancer Center (CN)
- Shanghai Pulmonary Hospital (CN)
- Shanghai First Maternity and Infant Hospital (CN)
- Viva Biotech (China) (CN)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s12929-025-01129-7
- Citations
- 7
- Primary Topic
- Histone Deacetylase Inhibitors Research
- Type
- article
- Field-Weighted Citation Impact
- 5.64