Evaluation of the Therapeutic Properties of the Aqueous Extract of <i>Picralima</i> <i>nitida</i> Seeds in Diabetic Rats

<i>Picralima nitida </i>seeds are used in traditional medicine to treat cough, bronchitis and headache, hernia, vomiting, diarrhea and finally leucorrhoea. The aim of this work was to evaluate the therapeutic effect of the aqueous extract of <i>Picralima seeds</i> <i>nitida </i>on hyperglycemia in rats. The antidiabetic activity of the aqueous extract of <i>P. nitida seeds </i>was evaluated in diabetic rats. For this purpose, diabetes was induced in rats by intraperitoneal injection of a single dose of 150 mg/kg MC of alloxan solution. After induction, rats were given anhydrous glucose solution (5%) overnight to overcome the hyperglycemic shock induced by the action of alloxan, and then the animals were treated. <i>P. nitida extract caused a marked recovery of body mass in diabetic rats. P. nitida </i>extract resulted in a significant reduction in induced hyperglycemia in diabetic rats. Regarding biochemical parameters, <i>P. nitida seeds </i>resulted in a marked improvement in the physiological state of rats by reducing biochemical parameters such as urea, ASAT, ALAT, creatinine, and uric acid as well as lipid and protein parameters. Administration of <i>P. nitida seeds </i>promoted the production of alpha amylase and lipase in diabetic rats. The use of this plant in the treatment of diabetic rats would therefore justify the therapeutic properties of <i>P. nitida seeds</i>.