Efficacy and mechanism of action of harmine derivative H-2-104 against Echinococcus granulosus infection in mice
H-2-104 exhibits significant activity both in vitro and in vivo, suggesting its potential as a promising new drug for the treatment of CE. The anti-CE effects of H-2-104 may be attributed to its regulation of multiple biological pathways, including cell apoptosis, amino acid metabolism, and glucose metabolism.
Authors
- Huijing Gao (ORCID: https://orcid.org/0000-0003-1910-5075)
- Kalibixiati Aimulajiang (ORCID: https://orcid.org/0000-0003-4491-0359)
- Qinwei Xu
- Bei Chen (ORCID: https://orcid.org/0000-0003-2553-3279)
- Jiang Zhu
- Liang Teng
- Jun Zhao (ORCID: https://orcid.org/0000-0001-6290-3262)
- Kadierya Kuerban
Institutions
- Xinjiang Medical University (CN)
- First Affiliated Hospital of Xinjiang Medical University (CN)
- Nanjing University of Science and Technology (CN)
- People's Hospital of Xinjiang Uygur Autonomous Region (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s12917-025-04642-x
- Citations
- 2
- Primary Topic
- Synthesis and bioactivity of alkaloids
- Type
- article
- Field-Weighted Citation Impact
- 1.61