Investigation of the synergistic effect of metformin and FX11 on PANC-1 cell lines
Compared with metformin treatment alone, the combination treatment of metformin and FX11 stimulates cellular stress in pancreatic cancer and targets various energy processes that encourage cancer cells to undergo apoptosis. This study provides a novel therapeutic strategy for the treatment of pancreatic cancer.
Authors
- Melike Bayindir-Bilgic (ORCID: https://orcid.org/0000-0002-0684-8905)
- Ayşegül Kuşkucu (ORCID: https://orcid.org/0000-0001-9265-7816)
- Utku Özbey (ORCID: https://orcid.org/0000-0001-5360-7998)
- Ömer Faruk Bayrak (ORCID: https://orcid.org/0000-0001-7562-6604)
- Dilara Turgut
- Ezgi Bakırcıoğlu Duman (ORCID: https://orcid.org/0009-0007-8504-5759)
- Ayse Naz Kadikoylu
- Nur Ekimci-Gurcan
Institutions
- Yeditepe University (TR)
- Biruni University (TR)
- Acıbadem Adana Hospital (TR)
Publication Details
- Journal
- Biological Research
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s40659-025-00592-8
- Citations
- 7
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 5.64