Short-term and long-term high-fat diet promote metabolic disorder through reprogramming mRNA m6A in white adipose tissue by gut microbiota
Together, this study reveals a novel mechanism that S-HFD and L-HFD induce metabolism disorder through gut microbiota-HGA-m<sup>6</sup>A-Ehmt2-ERV/LINE signaling. These findings may provide a novel insight for prevention and treatment of metabolism disorder upon short-term or long-term dietary fat intake. Video Abstract.
Authors
- Xinxia Wang (ORCID: https://orcid.org/0000-0002-2328-7003)
- Youhua Liu (ORCID: https://orcid.org/0000-0002-4740-805X)
- Chaoqun Huang (ORCID: https://orcid.org/0000-0002-8777-5479)
- Zimeng Xin
- Ruiti Ren
- Jiaqi Liu (ORCID: https://orcid.org/0009-0004-9262-3754)
- Yuxi Liu (ORCID: https://orcid.org/0009-0002-2876-8567)
- Yushi Chen (ORCID: https://orcid.org/0009-0002-7996-5122)
- Tongyudan Yang
- Yaojun Luo
Institutions
- Ministry of Agriculture and Rural Affairs (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Microbiome
- Published
- 2025-03-17
- DOI
- https://doi.org/10.1186/s40168-025-02047-4
- Citations
- 12
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 9.67
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China