Ocular Disease as a Comorbidity of Atopic Dermatitis

A variety of ocular disorders are commonly encountered in individuals affected by atopic dermatitis (AD). In addition to commonly observed ocular surface disease (OSD), other comorbid eye disorders seen inherently with AD include infections, keratoconjunctivitis, cataracts, and keratoconus. Some ocular diseases are recognized as potential adverse effects of therapies used to treat AD, especially topical and systemic corticosteroids, and biologic agents that inhibit interleukins (IL) 4 and/or 13. The latter includes dupilumab (IL-4/IL-13), tralokinumab (IL-13), and lebrikizumab (IL-13), all of which may be associated with OSD. This article serves to provide a thorough review of ocular diseases that are comorbidities of AD and/or occur in association with therapies used to treat AD.