Safety, tolerability, and pharmacokinetics of intranasal 2-deoxy-D-glucose in normal healthy volunteers: A randomized, double-blind, placebo-controlled, single and multiple ascending dose phase 1 study
Intranasal 2-deoxy-D-glucose, a novel intranasal therapeutic treatment for acute viral infections was safe and well-tolerated in healthy volunteers. These data support the further clinical development of 2-deoxy-D-glucose for treating viral infections in the target population (NCT05314933).
Authors
- Anna-Dorothea Gorki (ORCID: https://orcid.org/0000-0002-2521-0333)
- Nadja Haiden (ORCID: https://orcid.org/0000-0003-4806-0312)
- Scharon Chou
- Melanie Gsöellpointner
- Miriam M. Moser (ORCID: https://orcid.org/0009-0007-5317-1881)
- Thorsten Bischof (ORCID: https://orcid.org/0009-0003-8288-8591)
- Christa Firbas (ORCID: https://orcid.org/0000-0003-1927-4936)
- Katarina D. Kovacevic (ORCID: https://orcid.org/0000-0001-6774-714X)
- Guido A. Gualdoni (ORCID: https://orcid.org/0000-0001-9490-0197)
- Snezana Radivojev (ORCID: https://orcid.org/0009-0002-9186-0649)
- Christina Nicolodi (ORCID: https://orcid.org/0009-0000-5013-3782)
- Al Medina Dizdarevic
- Bernd Jilma (ORCID: https://orcid.org/0000-0001-5652-7977)
- Christian Mueller
- Christian Schoergenhofer
Institutions
- Johannes Kepler University of Linz (AT)
- Telstra (Australia) (AU)
- Sarepta Therapeutics (United States) (US)
- Medical University of Vienna (AT)
Publication Details
- Journal
- European Journal of Pharmaceutical Sciences
- Published
- 2025-03-16
- DOI
- https://doi.org/10.1016/j.ejps.2025.107069
- Citations
- 1
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.46