Clinical Outcome for Knee Osteoarthritis Patients Following Platelet-Rich Plasma Injection

Introduction: Knee osteoarthritis is a condition that affects joints causing pain and loss of function. Knee osteoarthritis increases with age and is more in the female population. Platelet-rich plasma has evolved as a promising treatment for knee osteoarthritis in decreasing knee pain and improving knee function in patients with knee osteoarthritis. This study aims to determine the outcome after using platelet-rich plasma injection in patients with osteoarthritis of the knee. Methods: This cohort study was conducted using medical records and data from patients who had undergone PRP injections for knee osteoarthritis at a tertiary care centre from 01 Jan 2022 to 30 Dec 2023 after obtaining ethical approval from the Ethical Review Board. Data of patients who have undergone platelet-rich plasma injection injections for knee osteoarthritis were collected retrospectively using records. Whole samplinlg technique was used. The measurement data are expressed as mean ± standard deviation (mean ±SD). IBM SPSS Statistics version 19.0 was used for statistical analysis. By using student’s paired t-tests, significant differences were compared in numerical pain scores at different follow-up visits. Results: There was a statistically significant (p-value less than 0.05) decrease in the NRS of the patients at three hours, one week, three weeks, and six months of PRP injection when compared to the preprocedural NRS. Among 91 patients, 73 (80.22%) were female and 18 (19.78%) were male. Mean age of male patients was 61.95 ± 13.21 years and female patients was 62.08 ± 12 years. Conclusion: Intra-articular PRP injections are highly effective in the treatment of knee osteoarthritis in decreasing pain and improving knee functionality.