RNA-binding Motif Proteins Influence Tumour Progression by Regulating Gene Expression

RNA binding motif (RBM) proteins are a class of RNA binding proteins, It's involved in a lot of functions in cells, they are involved in various physiological and pathological processes at multiple levels such as cell signal transduction, gene expression and body metabolism. They have been widely concerned by researchers due to their wide and stable expression in organisms. In recent years, many researchers have found that the RBM family is involved in the splicing of pre-mRNA, and plays an important role in maintaining the conformation of the catalytic core of the splicosome, and also acts as a bridge between the catalytic core and other essential protein components of the splicosome. Because of its wide range of gene expression regulation, the RBM protein family is associated with autoimmune diseases, inflammation and a variety of cancers, Many studies have shown that RBM protein family may be a therapeutic target for various diseases. This article reviews the role and mechanism of RBM protein family, especially in tumors, and provides reference for the treatment and prognosis of related diseases.