Correlation Between Clozapine and <scp>CRP</scp> Levels in Relation to Smoking Status
We report a significant correlation between CD of clozapine and CRP levels in non-smoking patients only. In these patients, clozapine CD is more than 3-fold higher at CRP > 50 versus CRP < 5. This suggests that non-smokers are most susceptible to clozapine side effects during inflammation or infection and represent patients where TDM analyses are especially important for guiding clozapine dosing.
Authors
- John M. Kane (ORCID: https://orcid.org/0000-0002-2628-9442)
- Espen Molden (ORCID: https://orcid.org/0000-0001-6190-2751)
- Robert L. Smith (ORCID: https://orcid.org/0000-0001-6789-7076)
- Georgios Schoretsanitis (ORCID: https://orcid.org/0000-0002-3851-4117)
- Ole A. Andreassen (ORCID: https://orcid.org/0000-0002-4461-3568)
Institutions
- Northwell Health (US)
- Feinstein Institute for Medical Research (US)
- University of Oslo (NO)
- University of Zurich (CH)
- University Hospital of Zurich (CH)
- Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US)
- Diakonhjemmet Hospital (NO)
- Zucker Hillside Hospital (US)
Publication Details
- Journal
- Acta Psychiatrica Scandinavica
- Published
- 2025-03-16
- DOI
- https://doi.org/10.1111/acps.13801
- Citations
- 9
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 13.24
Funders
- Helse Sør-Øst RHF