Joint analysis of the nPOD-Virus Group data: the association of enterovirus with type 1 diabetes is supported by multiple markers of infection in pancreas tissue
The nPOD-Virus Group conducted, to date, the largest and most comprehensive analysis of multiple indices of pancreatic enterovirus infections in type 1 diabetes; these were more prevalent in T1D-ICI and AAb<sup>++</sup> donors than in other groups. Their preferential detection of these indices in donors with residual beta cells and autoimmunity implicates enterovirus infections across disease progression stages and supports a contribution to beta cell loss, directly or indirectly, even after diagnosis. The relatively small number of infected cells and the low amount of viral RNA support the existence of non-acute, low level, possibly persistent enterovirus infections in the pancreas.
Authors
- Jutta E. Laiho (ORCID: https://orcid.org/0000-0002-5443-4651)
- Heikki Hyöty (ORCID: https://orcid.org/0000-0003-0370-4145)
- Kathrin Maedler (ORCID: https://orcid.org/0000-0002-7436-1197)
- Joseph F. Petrosino (ORCID: https://orcid.org/0000-0002-4046-6898)
- Alberto Pugliese (ORCID: https://orcid.org/0000-0002-7211-0319)
- Noel G. Morgan (ORCID: https://orcid.org/0000-0003-1537-8113)
- Matthias von Herrath (ORCID: https://orcid.org/0000-0002-5211-0485)
- Irina Kusmartseva (ORCID: https://orcid.org/0000-0003-2614-0813)
- Sofia Morfopoulou (ORCID: https://orcid.org/0000-0001-8181-4548)
- Sarah J. Richardson (ORCID: https://orcid.org/0000-0002-1160-6062)
- Julius O. Nyalwidhe (ORCID: https://orcid.org/0000-0003-2854-7510)
- Mark A. Atkinson (ORCID: https://orcid.org/0000-0001-8489-4782)
- Teresa Rodríguez-Calvo (ORCID: https://orcid.org/0000-0003-1531-8583)
- Vincent Plagnol (ORCID: https://orcid.org/0000-0002-5597-9215)
- John S. Kaddis (ORCID: https://orcid.org/0000-0002-6752-7670)
- Richard E. Lloyd (ORCID: https://orcid.org/0000-0002-6550-3237)
- Margaret A. Morris (ORCID: https://orcid.org/0000-0002-9063-9777)
- Jerry L. Nadler (ORCID: https://orcid.org/0000-0002-4200-6991)
Institutions
- University of Miami (US)
- Eastern Virginia Medical School (US)
- Tampere University (FI)
- University of Bremen (DE)
- Baylor College of Medicine (US)
- University of Exeter (GB)
- Helmholtz Zentrum München (DE)
- University of Florida (US)
- Autoimmune Technologies (United States) (US)
- City of Hope (US)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Fimlab (Finland) (FI)
- VA Northern California Health Care System (US)
- Beckman Research Institute
- University College London (GB)
- University of California, Davis (US)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-03-16
- DOI
- https://doi.org/10.1007/s00125-025-06401-x
- Citations
- 10
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 18.17
Funders
- Leona M. and Harry B. Helmsley Charitable Trust
- City of Hope
- Human Islet Research Network
- Diabetes UK
- Deutsche Forschungsgemeinschaft
- Medical Research Council
- FP7 Health