Impact of HLA alloimmunization in gene-modified autologous stem cell transplant for transfusion-dependent thalassemia
We report our single-center experience demonstrating that HLA class I alloimmunization predicts longer time to platelet engraftment, increased bleeding complications, and higher transfusion requirements in patients undergoing gene-modified hematopoietic stem cell transplant for transfusion-dependent β thalassemia.
Authors
- Nora M. Gibson
- Timothy S. Olson (ORCID: https://orcid.org/0000-0003-1288-1960)
- Elizabeth Worster (ORCID: https://orcid.org/0000-0003-4630-5945)
- Eugene Khandros (ORCID: https://orcid.org/0000-0003-2313-9710)
- Alexis A. Thompson (ORCID: https://orcid.org/0000-0003-4961-8103)
- Caitlin W. Elgarten (ORCID: https://orcid.org/0000-0002-2474-3031)
- Janet L. Kwiatkowski (ORCID: https://orcid.org/0000-0001-7103-3406)
- Dimitrios Monos
Institutions
- Children's Hospital of Philadelphia (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Blood
- Published
- 2025-03-16
- DOI
- https://doi.org/10.1182/blood.2024027034
- Citations
- 5
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 8.85