Lymphoid malignancies in patients with Shwachman-Diamond syndrome

This study identified an increased risk of lymphoid malignancy in Shwachman-Diamond syndrome (SDS) with an observed risk 38-fold higher than expected based on population data. Increased toxicity was observed with standard therapies in patients with SDS.

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Publication Details

Journal
Blood
Published
2025-03-16
DOI
https://doi.org/10.1182/blood.2024026507
Citations
1
Primary Topic
Blood disorders and treatments
Type
article
Field-Weighted Citation Impact
1.82
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article

Lymphoid malignancies in patients with Shwachman-Diamond syndrome

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1 citations
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Blood disorders and treatments
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article

Lymphoid malignancies in patients with Shwachman-Diamond syndrome

Edie A. Weller, Kasiani C. Myers, Maggie Malsch, Sara Loveless, Harrison Kwei Tsai, Christopher Gamper, Marian H. Harris, Akiko Shimamura, Sarah K. Steltz, Helen D. Reed, Jason E. Farrar, Christopher R. Reilly, Lauren Pommert, Margret Joos, Leah Cheng, Bonnie Lau, Ian C. Atkinson, Hyunwoo Do, Katherine Coyne
article en
1 citations

Abstract

This study identified an increased risk of lymphoid malignancy in Shwachman-Diamond syndrome (SDS) with an observed risk 38-fold higher than expected based on population data. Increased toxicity was observed with standard therapies in patients with SDS.

BloodVol. 145(21)
Dartmouth College (US), Dartmouth Institute for Health Policy and Clinical Practice (US), Cincinnati Children's Hospital Medical Center (US), Boston Children's Hospital (US), Arkansas Children's Hospital (US), Harvard University (US), Johns Hopkins University (US), Johns Hopkins Medicine (US), Dana-Farber Cancer Institute (US), Dartmouth Psychiatric Research Center (US), Arkansas Children's Nutrition Center (US), Boston Children's Museum (US), Dana-Farber/Boston Children's Cancer and Blood Disorders Center (US), University of Baltimore (US), University of Arkansas for Medical Sciences (US), University of Cincinnati Medical Center (US)
Good health and well-being
Openalex Percentile: Top 18%
Blood disorders and treatments
1.82
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