EVALUATION OF THE PREDICTIVE ABILITY OF LABORATORY PARAMETERS IN FIBROMYALGIA SYNDROME COMPARED TO INDIVIDUALS WITH LOCAL MUSCULOSKELETAL PAIN

Introduction: Fibromyalgia syndrome (FMS) is a chronic pain syndrome characterized by widespread pain and various somatic symptoms. This study aims to investigate the differences between FMS patients and individuals with localized musculoskeletal disorders by evaluating inflammatory and metabolic markers that may play a role in FMS pathogenesis. Methods: This retrospective study included 43 patients diagnosed with FMS and 43 patients with localized musculoskeletal pain, aged between 30 and 65 years. White blood cell count (WBC), red cell distribution width (RDW), mean corpuscular haemoglobin concentration (MCHC), mean platelet volume (MPV), platelet distribution width (PDW), albumin, creatinine, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) values of the participants were recorded. Additionally, CRP/albumin ratio (CAR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), and systemic inflammatory indices (SII) of the participants were calculated. Results: The mean ages were similar between the two groups in our study (Group 1 mean age: 46.76±8.94 years and Group 2 mean age: 46.3±8.67 years). MPV levels were found to be statistically significantly higher in the FMS group compared to the group with localized pain (p=0.02). No statistically significant difference was detected between the two groups in terms of the other evaluated laboratory parameters. Conclusions: According to our research, we found a statistically significant difference only in MPV levels between FMS patients and controls. This suggests that it may help facilitate the diagnosis of FMS patients.