Genetic insights into idiopathic pulmonary fibrosis: a multi-omics approach to identify potential therapeutic targets
We identified six key genes-ANO9, BRCA1, CCDC200, EZH1, FAM13A, and SFR1-as potential drug targets for IPF. Molecular docking revealed strong drug affinities, while PheW-MR analysis highlighted therapeutic potential and associated risks. These findings offer new insights for IPF treatment and further investigation of potential side effects.
Authors
- Zisheng Chen
- Kun‐Ta Lin (ORCID: https://orcid.org/0000-0001-5942-6880)
- Jing Yang (ORCID: https://orcid.org/0000-0002-9581-5979)
- Rui-Ming Xu (ORCID: https://orcid.org/0000-0002-5948-8579)
- Wenpeng Liang (ORCID: https://orcid.org/0009-0002-8594-5988)
- Junjie Liu (ORCID: https://orcid.org/0000-0001-7060-6663)
- Pan Jia
- Zhuofeng Wen
- Zhongxia Yang (ORCID: https://orcid.org/0000-0001-8156-442X)
Institutions
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Qiqihar Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-16
- DOI
- https://doi.org/10.1186/s12967-025-06368-8
- Citations
- 6
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 9.11