ESM1 suppresses LncRNA GAS5/miR-23a-3p/PTEN axis to promote the cisplatin-chemotherapy resistance of ovarian cancer cells via activating the PI3K/AKT pathway
ESM1 promotes OC cisplatin resistance by activating the Phosphoinositide-3-Kinase (PI3K)/AKT Serine/Threonine Kinase (Akt) signaling pathway through the GAS5/miR-23a-3p/PTEN signaling axis. This suggests that prescriptive ESM1 regulates key downstream molecular mechanisms via non-coding RNA and can be used before neoadjuvant chemotherapy in OC is initiated.
Authors
- Xing Tang (ORCID: https://orcid.org/0000-0001-5570-2155)
- Mei Qin
- Hui Li (ORCID: https://orcid.org/0000-0002-3526-6664)
- Wenchao Zhou (ORCID: https://orcid.org/0000-0002-6650-1831)
- Peng Wu (ORCID: https://orcid.org/0000-0002-3909-0774)
- Shuanghua Chen
- Juan Zou (ORCID: https://orcid.org/0000-0002-1229-5243)
- Juan Zhang (ORCID: https://orcid.org/0000-0001-5089-723X)
- Yukun Li (ORCID: https://orcid.org/0000-0002-5169-4693)
- Tingyu Fan (ORCID: https://orcid.org/0000-0002-1530-1928)
- Tian Zeng (ORCID: https://orcid.org/0000-0002-5704-2848)
- Jiawen Fang (ORCID: https://orcid.org/0000-0002-1118-7689)
- Yuwei Yuan
- Ting Yi (ORCID: https://orcid.org/0009-0006-3239-3832)
Institutions
- Central South University (CN)
- Hunan Academy of Traditional Chinese Medicine (CN)
- Zhuzhou Central Hospital (CN)
- Heilongjiang University (CN)
- University of South China (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-03-16
- DOI
- https://doi.org/10.1007/s12672-025-02113-1
- Citations
- 3
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hainan Province