Phosphine-mediated [2+3]/[2+3] domino annulation reaction: access to cyclopentane[3,4]pyrrolo[1,2-<i>a</i>]indoles

A phosphine-mediated [2+3]/[2+3] domino annulation reaction between indole-derived enones and Morita-Baylis-Hillman (MBH) carbonates was discovered, delivering a series of cyclopentane[3,4]pyrrolo[1,2-<i>a</i>]indoles with up to 87% yield and >20 : 1 dr.

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Publication Details

Journal
Chemical Communications
Published
2025-01-01
DOI
https://doi.org/10.1039/d5cc00618j
Citations
2
Primary Topic
Asymmetric Synthesis and Catalysis
Type
article
Field-Weighted Citation Impact
1.87
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article

Phosphine-mediated [2+3]/[2+3] domino annulation reaction: access to cyclopentane[3,4]pyrrolo[1,2-a]indoles

Yannan Zhu, Yuxuan Zhu, Yumeng Li, Nan He et al.
2 citations
Chemical Communications
Asymmetric Synthesis and Catalysis
1.87
article

Phosphine-mediated [2+3]/[2+3] domino annulation reaction: access to cyclopentane[3,4]pyrrolo[1,2-a]indoles

Yannan Zhu, Yuxuan Zhu, Yumeng Li, Nan He, Gang Qi
article en
2 citations

Abstract

A phosphine-mediated [2+3]/[2+3] domino annulation reaction between indole-derived enones and Morita-Baylis-Hillman (MBH) carbonates was discovered, delivering a series of cyclopentane[3,4]pyrrolo[1,2-<i>a</i>]indoles with up to 87% yield and >20 : 1 dr.

Chemical CommunicationsVol. 61(32)
Yancheng Institute of Technology (CN)
Openalex Percentile: Top 17%
Asymmetric Synthesis and Catalysis
1.87
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