Malignant Hypertension Mimicking Pulmonary-Renal Syndrome

Pulmonary renal syndrome (PRS) is a rare clinical syndrome characterized by pulmonary hemorrhage and rapidly progressing glomerulonephritis. It is commonly due to a rheumatologic etiology, including antineutrophil cytoplasm antibodies vasculitis or antiglomerular basement membrane disease. Given the rapid progression, patients are often empirically treated when there is high clinical suspicion for PRS. Few case reports have shown malignant hypertension (HTN) as a mimicker of PRS. We present a case of a patient with dyspnea, hemoptysis, and hematuria where there was high suspicion for PRS, and immunosuppression was initiated, but in the end, the etiology was malignant HTN. Malignant HTN can lead to multiple end-organ damage, including the lungs and kidneys; thus, it is important to consider malignant HTN in the differential. Overall, we report a case of malignant HTN mimicking PRS.

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Publication Details

Journal
Cureus
Published
2025-03-16
DOI
https://doi.org/10.7759/cureus.80654
Primary Topic
Coagulation, Bradykinin, Polyphosphates, and Angioedema
Type
article
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article

Malignant Hypertension Mimicking Pulmonary-Renal Syndrome

Shannon M Lee, Aida F. Martinez, Nathan Yee
Cureus
Coagulation, Bradykinin, Polyphosphates, and Angioedema
article

Malignant Hypertension Mimicking Pulmonary-Renal Syndrome

Shannon M Lee, Aida F. Martinez, Nathan Yee
article en

Abstract

Pulmonary renal syndrome (PRS) is a rare clinical syndrome characterized by pulmonary hemorrhage and rapidly progressing glomerulonephritis. It is commonly due to a rheumatologic etiology, including antineutrophil cytoplasm antibodies vasculitis or antiglomerular basement membrane disease. Given the rapid progression, patients are often empirically treated when there is high clinical suspicion for PRS. Few case reports have shown malignant hypertension (HTN) as a mimicker of PRS. We present a case of a patient with dyspnea, hemoptysis, and hematuria where there was high suspicion for PRS, and immunosuppression was initiated, but in the end, the etiology was malignant HTN. Malignant HTN can lead to multiple end-organ damage, including the lungs and kidneys; thus, it is important to consider malignant HTN in the differential. Overall, we report a case of malignant HTN mimicking PRS.

CureusVol. 17(3)
UCLA Medical Center (US)
Openalex Percentile: Top 93%
Coagulation, Bradykinin, Polyphosphates, and Angioedema
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