Whole-body muscle MRI in patients with spinal muscular atrophy
Certain muscles are more prone to fat replacement than others in SMA, with a predominant proximal-distal and extensor-flexor involvement. Nearly half of the patients had increased fat content in the tongue, which is associated with dysphagia. In addition, most patients retained muscle strength in the bulbar muscles, despite advanced muscle weakness in the rest of the body.
Authors
- John Vissing (ORCID: https://orcid.org/0000-0001-6144-8544)
- Stefanie Frölich
- Adam E. Hansen (ORCID: https://orcid.org/0000-0002-6457-1537)
- Nanna Scharff Poulsen (ORCID: https://orcid.org/0000-0002-3739-8759)
- Noémie Receveur (ORCID: https://orcid.org/0009-0004-2959-361X)
Institutions
- Rigshospitalet (DK)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-03-16
- DOI
- https://doi.org/10.1007/s00415-025-13005-3
- Citations
- 6
- Primary Topic
- Neurogenetic and Muscular Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 9.75
Funders
- Rigshospitalet
- Novo Nordisk Fonden