Single-cell transcriptomic analysis reveals dynamic changes in the liver microenvironment during colorectal cancer metastatic progression
A Prok2⁺ neutrophil subpopulation infiltrated both pre-metastatic and macro-metastatic liver environments, potentially driving immunosuppression through macrophage inhibition and T-cell exhaustion. Targeting Prok2⁺ neutrophils could represent a novel therapeutic strategy for preventing liver metastasis in colorectal cancer patients.
Authors
- Bing Cheng (ORCID: https://orcid.org/0000-0002-8845-7544)
- Weidong Pan (ORCID: https://orcid.org/0000-0002-0380-4210)
- Guojie Long
- Xiaoming Huang (ORCID: https://orcid.org/0000-0002-7156-8897)
- Wenyu Wang (ORCID: https://orcid.org/0000-0001-8947-4867)
- Yue Jiang (ORCID: https://orcid.org/0000-0002-7725-272X)
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-03-16
- DOI
- https://doi.org/10.1186/s12967-025-06351-3
- Citations
- 9
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 9.41
Funders
- National Natural Science Foundation of China
- Fundamental Research Funds for the Central Universities