Task-Dependent Functional Coupling of the Amygdala Network in Response to Drug Cues in Individuals with Methamphetamine Use Disorder

These discoveries enrich our comprehension of the neural mechanisms at play in methamphetamine cue reactivity and addiction-related processes. The increased amygdala-cortical connectivity underscores the role of these networks in drug cue processing, potentially contributing to craving and relapse. Effective connectivity analysis highlights the interconnectedness of the amygdala, dlPFC, and PCC, revealing potential pathways for neural signaling during cue reactivity. Our results contribute to the growing body of knowledge about addiction's neurobiological basis, offering insights that may inform targeted interventions to mitigate the impact of methamphetamine cue reactivity on addiction progression.