Association of plasma metabolites with treatment response after intravitreal anti-vascular endothelial growth factor injections in treatment-naïve neovascular age-related macular degeneration
In our study, TDCA was the most significant plasma metabolite associated with treatment response after three-loading dose of anti-VEGF therapy in patients with nAMD. Bile acids may have a beneficial impact on treatment response in nAMD through their neuroprotective property. Plasma metabolites may be used as biomarkers to predict responses to initial anti-VEGF therapy in patients with nAMD, providing a more individualised treatment plan.
Authors
- Jessica Ann Lasky-Su (ORCID: https://orcid.org/0000-0001-6236-4705)
- Archana Nigalye (ORCID: https://orcid.org/0000-0003-1468-7766)
- Hae Min Kang (ORCID: https://orcid.org/0000-0001-7675-0180)
- Ivana K. Kim (ORCID: https://orcid.org/0000-0003-0310-6129)
- Inês Laíns (ORCID: https://orcid.org/0000-0002-8136-4724)
- Kevin Mendez (ORCID: https://orcid.org/0000-0002-8832-2607)
- Raviv Katz (ORCID: https://orcid.org/0000-0002-5305-8551)
- Rodrigo Alvarez (ORCID: https://orcid.org/0000-0002-3368-4598)
- Roshni Bhat
- Liming Liang (ORCID: https://orcid.org/0000-0001-8261-3174)
- John B. Miller (ORCID: https://orcid.org/0000-0003-0109-9738)
- Augustine Bannerman
- Hanna Choi (ORCID: https://orcid.org/0000-0003-4966-5321)
- Joan W. Miller (ORCID: https://orcid.org/0000-0003-2046-3996)
- Georgiy Kozak
- Demetrios G. Vavvas (ORCID: https://orcid.org/0000-0002-8622-6478)
- David T. Wu (ORCID: https://orcid.org/0000-0002-1948-4565)
- Deeba Husain (ORCID: https://orcid.org/0000-0002-8494-0950)
- Krupa Sourirajan
Institutions
- Brigham and Women's Hospital (US)
- Massachusetts Eye and Ear Infirmary (US)
- Harvard University (US)
- Xianning Central Hospital (CN)
Publication Details
- Journal
- BMJ Open Ophthalmology
- Published
- 2025-03-01
- DOI
- https://doi.org/10.1136/bmjophth-2025-002149
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Research to Prevent Blindness
- National Institutes of Health