Network pharmacology and experimental analysis reveal Ethyl caffeate delays osimertinib resistance in lung cancer by suppression of MET
FYN might delay osimertinib resistance by downregulating the expression of MET, which can be attributed to its active ingredient, Ethyl caffeate.
Authors
- Shuliu Sang (ORCID: https://orcid.org/0000-0002-7601-632X)
- Yang Han (ORCID: https://orcid.org/0000-0002-0034-5848)
- Yabin Gong (ORCID: https://orcid.org/0000-0002-6811-101X)
- Xiaohong Kang
- Hailun Zhou
Institutions
- Shanghai University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Xinxiang Medical University (CN)
- Yueyang Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-03-15
- DOI
- https://doi.org/10.1186/s12935-025-03690-5
- Citations
- 2
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China